Current status

In August 2022, the below number of individuals have been recruited in Swedegene. DNA and clinical data collection for these are completed.

ADR type Number
Angioedema 542
Anaphylaxis 137
Urticaria 204
Other allergic reactions 120
Cough related to ACE-inhibitors 150
Osteonecrosis and atypical fractures due to bisphosphonates 138
Phototoxic reactions (mainly due to topical NSAIDs) 51
Blood cell dyscrasia (agranulocytosis, thrombocytopenia and anemia) to non-cytostatic drugs  299
Metabolic reactions from neuroleptics and antidepressants (mainly weight gain) 72
Hyponatremia/SIADH due to antidepressants and antiepileptics 39
CNS toxicity and neuropsychiatric reactions from antiviral therapy and antibiotics 95
Stevens-Johnson syndrome/Toxic epidermal necrolysis 66
Tendon-rupture from flouroquinolones 31
Liver toxicity 462
Rhabdomyolysis related to statins/fibrates 54
Torsade de Pointes/QT-prolongation 26
Narcolepsy associated with Pandemrix 83
Hypersomnia associated with Pandemrix 12
Pancreatitis 96
Alopecia 28
Bleedings from new oral anticoagulants (NOACs) 141
Lack of efficacy of NOACs 32
Pneumonitis 28
Renal toxicity 89
Ankle oedema from calcium channel blockers 17
Gingival hyperplasia from calcium channel blockers 8
Adverse reactions to Covid-19 vaccines 412
Controls 580
Total number of cases 3835

ACE = angiotensin converting enzyme; NSAID = non-steroidal anti-inflammatory drug; NOAC=non-vitamin K oral anticoagulant drug.

Note that the number of cases for a particular ADR may be greater than the total number of cases as some individuals have experienced multiple ADRs concomitantly.