Current status

 

As of June 1, 2017, the below number of cases have been recruited in Swedegene. DNA and clinical data collection for these cases are completed.

 

ADR type

Number of cases

Angioedema (mainly related to ACE-inhibitors/ARBs)

479

Cough related to ACE-inhibitors

151

Osteonecrosis and atypical fractures due to bisphosphonates

107

Phototoxic reactions (mainly due to topical NSAIDs)

48

Drug hypersensitivity, mainly antibiotics and NSAIDs

313

Metabolic reactions from neuroleptics and antidepressants (mainly weight gain)

46

Hyponatremia/SIADH due to antidepressants and antiepileptics

36

CNS toxicity and neuropsychiatric reactions from antiviral therapy and antibiotics

80

Stevens-Johnson syndrome/Toxic epidermal necrolysis

58

Tendon-rupture from flouroquinolones

24

Liver toxicity

270

Rhabdomyolysis related to statins/fibrates

48

Torsade de Pointes/QT-prolongation

17

Agranulocytosis and neutropenia from non-chemotherapeutic agents

172

Thrombocytopenia

51

Narcolepsy associated with Pandemrix

64

Pancreatitis

79

Ototoxicity and vestibular toxicity

6

Alopecia

26

Bleedings from new oral anticoagulants (NOACs)

52

Other blood cell dyscrasia

15

Renal toxicity

50

Other

342

Total number of cases

2529


ACE = angiotensin converting enzyme; ARB = angiotensin II type 1 receptor blocker; NSAID = non-steroidal anti-inflammatory drug.

 

Note that the number of cases for a particular ADR may be greater than the total number of cases as some individuals have experienced multiple ADRs concomitantly.